Streptococcus thermophilus adapts exceptionally well to plant-based fermentations and is a strong producer of bioactive EPS. These EPS naturally function as a prebiotic feeding beneficial gut bacteria, improving digestion, and strengthening the intestinal barrier, while also helping to scavenge free radicals, protect cells from damage, and produce anti-inflammatory effects in your system.

Benefits Include:

Better Digestion, Less Bloating, Gut Health Support, Stronger Immune Support, and Reduced Inflammation

Select Studies:

1. Gezginç, Y., Karabekmez-erdem, T., Tatar, H. D., Ayman, S., Ganiyusufoğlu, E., & Dayısoylu, K. S. (2022). Health-promoting benefits of postbiotics produced by lactic acid bacteria: Exopolysaccharide. Biotech Studies, 31(2), 61-70. https://doi.org/10.38042/biotechstudies.1159166
2. Chen, Y.; Zhang, M.; Ren, F. A Role of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis. Molecules 2019, 24, 513. https://doi.org/10.3390/molecules24030513
3. Sanhueza-Carrera EA, Cantero-Ramírez C, Montijo-Valdés AD, Rodríguez-Valladares CG, Fernández-Lainez C, García-Torres I, Gutiérrez-Castrellón P, González-Zamora JF, López-Velázquez G. The Role of Microbial Exopolysaccharides in Preventing and Treating Cardiovascular Diseases. Microorganisms. 2025 Jun 29;13(7):1522. doi: 10.3390/microorganisms13071522. PMID: 40732030; PMCID: PMC12299704. https://pmc.ncbi.nlm.nih.gov/articles/PMC12299704/
4. Han F, Wu G, Zhang Y, Zheng H, Han S, Li X, Cai W, Liu J, Zhang W, Zhang X, Hu D. Streptococcus thermophilus Attenuates Inflammation in Septic Mice Mediated by Gut Microbiota. Front Microbiol. 2020 Dec 15;11:598010. doi: 10.3389/fmicb.2020.598010. PMID: 33384671; PMCID: PMC7769777. https://pmc.ncbi.nlm.nih.gov/articles/PMC7769777/

Lactobacillus bulgaricus ensures a clean and stable fermentation, helping to aid in digestion, maintain microbial balance, and improve nutrient absorption, especially for lactose-intolerant individuals, while also boosting immunity by producing lactic acid and beneficial compounds that inhibit pathogens and support the gut barrier.

Benefits Include:

Better Oral Health and Fresher Mouth, Better Digestion, Gut Health Support, Stronger Immune Support, and a Balanced Microbiome

Select Studies:

1. Yamamoto Y, Fujino K, Saruta J, Takahashi T, To M, Fuchida S, Shimizu T, Kamata Y, Misawa K, Tsukinoki K. Effects of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on the IgA flow rate of saliva in elderly persons residing in a nursing home: A before-after non-randomised intervention study. Gerodontology. 2017 Dec;34(4):479-485. doi: 10.1111/ger.12296. Epub 2017 Aug 23. PMID: 28836348. https://pubmed.ncbi.nlm.nih.gov/28836348/
2. Shuyi Tang, Takehiro Yokoo, Takayuki Toshimitsu, Toshihiro Sashihara, Yoshitaka Iwama, Satoshi Hachimura, Kenichi Hojo, Yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 and Streptococcus thermophilus OLS3059 enhances dendritic cell activity and reduces cold-like symptoms in healthy adults: A randomized controlled trial, Journal of Functional Foods, Volume 137, 2026, 107154, ISSN 1756-4646. https://doi.org/10.1016/j.jff.2026.107154
3. Banerjee P, Merkel GJ, Bhunia AK. Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells. Gut Pathog. 2009 Apr 27;1(1):8. doi: 10.1186/1757-4749-1-8. PMID: 19397787; PMCID: PMC2680912. https://pmc.ncbi.nlm.nih.gov/articles/PMC2680912/
4. Kobayashi, K., Mochizuki, J., Yamazaki, F., & Sashihara, T. (2024). Yogurt starter strains ameliorate intestinal barrier dysfunction via activating AMPK in Caco-2 cells. Tissue Barriers, 12(1). https://doi.org/10.1080/21688370.2023.2184157
5. Kobayashi K, Imai Y, Shimizu Y, Ogawa I, Nakai T, Mizuno Y, Kaneda Y, Watanabe-Yasuoka Y, Yamazaki F, Mochizuki J, Sashihara T, Matsunaga T, Iwao T. Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus structural small intestine. Front Immunol. 2025 Jun 11;16:1585007. doi: 10.3389/fimmu.2025.1585007. PMID: 40568574; PMCID: PMC12190435. https://pmc.ncbi.nlm.nih.gov/articles/PMC12190435/

Lactobacillus plantarum is a powerful plant-origin probiotic that produces antioxidants, peptides, and biome-active metabolites. It remains highly active in plant-based fermentations and supports gut resilience, digestive comfort, and microbiome diversity. This strain contributes strongly to overall wellness and metabolic balance.

Benefits Include:

Better Digestion, Gut Health Support, and a Balanced Microbiome

Select Studies:

1. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol. 2012 Aug 14;18(30):4012-8. doi: 10.3748/wjg.v18.i30.4012. PMID: 22912552; PMCID: PMC3419998. https://pmc.ncbi.nlm.nih.gov/articles/PMC3419998/
2. Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen,Lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-Blind, Placebo-Controlled, Pilot Clinical Trial,Engineering,Volume 7, Issue 3,2021,Pages 376-385,ISSN 2095-8099. https://doi.org/10.1016/j.eng.2020.06.026
3. Sohn M, Jung H, Lee WS, Kim TH, Lim S. Effect of Lactobacillus plantarum LMT1-48 on Body Fat in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes Metab J. 2023 Jan;47(1):92-103. doi: 10.4093/dmj.2021.0370. Epub 2022 Apr 29. PMID: 35487505; PMCID: PMC9925147. https://pmc.ncbi.nlm.nih.gov/articles/PMC9925147/
4. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol. 2012 Aug 14;18(30):4012-8. doi: 10.3748/wjg.v18.i30.4012. PMID: 22912552; PMCID: PMC3419998. https://pmc.ncbi.nlm.nih.gov/articles/PMC3419998/

Lactobacillus casei thrives in plant-derived environments and is widely studied for its role in enhancing immune resistance. It produces beneficial postbiotics that help modulate immune function and maintain a healthy biome ecosystem, while also helping to reduce bloating and discomfort, regulate digestion, and, in some studies, benefit the oral biome in the way it fights negative bacteria in the mouth.

Benefits Include:

Better Oral Health, Clearer Skin, Gut Health Support, Stronger Immune Support, and a Balanced Microbiome

Select Studies:

1. Rizzardini G, Eskesen D, Calder PC, Capetti A, Jespersen L, Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2012 Mar;107(6):876-84. doi: 10.1017/S000711451100420X. Epub 2011 Sep 7. PMID: 21899798. https://pubmed.ncbi.nlm.nih.gov/21899798/
2. Koebnick C, Wagner I, Leitzmann P, Stern U, Zunft HJ. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can J Gastroenterol. 2003 Nov;17(11):655-9. doi: 10.1155/2003/654907. PMID: 14631461. https://pubmed.ncbi.nlm.nih.gov/14631461/
3. Lee MK, Chen IH, Hsu IL, Tsai WH, Lee TY, Jhong JH, Liu BC, Huang TY, Lin FK, Chang WW, Wu JH. The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial. BMC Oral Health. 2024 Apr 20;24(1):477. doi: 10.1186/s12903-024-04251-4. PMID: 38643116; PMCID: PMC11031891. https://pmc.ncbi.nlm.nih.gov/articles/PMC11031891/

LGG is one of the most researched probiotic strains globally and supports gut and immune wellness. Clinical research shows LGG can help individuals with atopic dermatitis by improving the gut–skin connection. It also strengthens the body’s natural barrier by supporting tight-junction repair and reducing unwanted gut permeability. In plant-based fermentations, LGG stays highly active, making it a powerful contributor to biome balance and skin health.

Benefits Include:

Better Oral Health, Clearer Skin, and a Balanced Microbiome

Select Studies:

1. Alanzi A, Honkala S, Honkala E, Varghese A, Tolvanen M, Söderling E. Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health, dental plaque, and periodontopathogens in adolescents: a randomised placebo-controlled clinical trial. Benef Microbes. 2018 Jun 15;9(4):593-602. doi: 10.3920/BM2017.0139. Epub 2018 Apr 10. PMID: 29633646. https://pubmed.ncbi.nlm.nih.gov/29633646/
2. Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło-Mylik MA, Konopka E, Trojanowska I, Zakrzewska M, Bierła JB, Zakrzewski M, Kanarek E, Motyl I. The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow's Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021 Apr 1;13(4):1169. doi: 10.3390/nu13041169. PMID: 33916192; PMCID. https://pmc.ncbi.nlm.nih.gov/articles/PMC8066586/

BB-12 is a leading bifidobacterium known for improving gut transit, digestive comfort, and immune support. It contributes to the formation of SCFA precursors, helping butyrate-producing microbes thrive in the colon. In gentle plant-based fermentation, BB-12 remains highly active and delivers reliable digestive and wellness benefits.

Benefits Include:

Gut Health Support, Better Digestion, Less Bloating, and a Balanced Microbiome

Select Studies:

1. Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. doi: 10.3390/microorganisms2020092. PMID: 27682233; PMCID: PMC5029483. https://pmc.ncbi.nlm.nih.gov/articles/PMC5029483/
2. Luo, M., Xie, P., Deng, X., Fan, J. and Xiong, L. (2025), Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism. Journal of Gastroenterology and Hepatology, 40: 1561-1573. https://doi.org/10.1111/jgh.16960
3. Al-Sadi R, Dharmaprakash V, Nighot P, Guo S, Nighot M, Do T, Ma TY. Bifidobacterium bifidum Enhances the Intestinal Epithelial Tight Junction Barrier and Protects against Intestinal Inflammation by Targeting the Toll-like Receptor-2 Pathway in an NF-κB-Independent Manner. Int J Mol Sci. 2021 Jul 28;22(15):8070. doi: 10.3390/ijms22158070. PMID: 34360835; PMCID: PMC8347470. https://pubmed.ncbi.nlm.nih.gov/34360835/